Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas: A cooperative clinical trial

摘要: ✓ A controlled, prospective, randomized study evaluated the use of 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) and/or radiotherapy in treatment patients who were operated on and had histological confirmation anaplastic glioma. total 303 into this study, whom 222 (73%) within Valid Study Group (VSG), having met protocol criteria neuropathology, corticosteroid control, therapeutic approach. Patients divided four random groups, received BCNU (80 mg/sq m/day 3 successive days every 6 to 8 weeks), (5000 6000 rads whole brain through bilateral opposing ports), or best conventional care but no chemotherapy radiotherapy. Analysis was performed all any amount therapy (VSG) Adequately Treated (ATG), 5000 more radiotherapy, two courses chemotherapy, a minimum survival weeks (the interval that would have b...