Chapter 10 Modified Nucleosides as Biochemical Markers of Asbestos Exposure and Aids

摘要: Publisher Summary Cancer patients and tumor-bearing animals excrete in their urine increased amounts of modified purines pyrimidines. These nucleosides, synthesized at the macro-molecular level are primarily constituents tRNA to a lesser extent other RNAs. Slight elevations urinary nucleoside excretion from subjects with bacterial pneumonia significant some tract infections have been noticed. Elevated levels nucleosides bases precede appearance tumor. Modified 24 hours samples were determined initiation experiment until demise animals. By seventh week, when tumor was not diagnosable, elevated. The protracted period latency poses difficult problem for early detection, especially, successful therapy. information obtained retrospective prospective epidemiological investigations asbestos insulation workers provides evidence serious consequences that may occur there has delay establishing cause-effect relationship, biological biochemical events during remain poorly understood.