Molecular biology of adenosine triphosphate-sensitive potassium channels.

摘要: I. Introduction II. How Are KATP Channels Defined? III. Do Affect the Membrane Potential of Pancreatic β-Cells? IV. Channel Subunits A. The KIR family inwardly rectifying K+ channels B. Sulfonylurea receptors V. Reconstitution Activity from SUR1 and KIR6.2 question “promiscuous coupling” with other inward rectifiers VI. Structure forms pore a channel KIR6.x are physically associated C. Coexpression affects maturation D. Complex glycosylated assemble large multimer E. A 1:1 stoichiometry SUR to is both necessary sufficient make F. Other tetramers G. active β-cell (SUR1/KIR6.2)4 VII. Regulation do ATP ADP exert their effects on channels? Where nucleotide binding sites located? C-terminally truncated show abnor...