Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.

摘要: Adenosine triphosphate (ATP)-sensitive potassium channels (K ATP ) exist in cardiac tissue and a potential role the pathogenesis of myocardial ischemia was hypothesized early after their discovery. Studies vitro models reperfusion have indicated that K openers, as class, exert protective effects. This has been assessed by determination recovery contractile function, inhibition contracture, or necrosis. effect appears to be exerted directly on myocardium is not dependent peripheral coronary dilator activities. These effects are uniformly abolished blockers