Adenosine, KATP Channel, and Cardioprotection in the Intact Heart

摘要: Recent breakthroughs in our understanding of the endogenous defense mechanisms heart to ischemia have made it possible develop novel and efficacious therapeutics for treating myocardial ischemia. Of particular interest is adenosine-KATp axis. Development this area was based on intersection several independent lines investigation. The preconditioning brought KATP adenosine researchers together seems likely that there a real interaction between two systems. While we learned much, still long way go. If one assumes activation “downstream” receptor activation, mechanism by which exerts cardioprotection unknowa This probably most important remaining questioa Current progress being identify subtype involved with may be mitochondrial. case, will imperative determine opening these channels can exert cardioprotective energy sparing effects. Determination potentially lead development therapeutics.