Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions.
作者： Joel Linden
DOI: 10.1016/0165-6147(94)90011-6
关键词: Adenosine A3 receptor 、 Immune receptor 、 Purinergic signalling 、 Pharmacology 、 Receptor 、 Biology 、 Adenosine A3 Receptor Antagonists 、 Endocrinology 、 Adenosine A2B receptor 、 Protease-activated receptor 2 、 Internal medicine 、 Adenosine receptor
摘要: In this review, Joel Linden summarizes what is known about a new and intriguing member of the adenosine receptor family, A3 receptor. This exhibits unusually large differences in structure, tissue distribution pharmacological properties between species. Rat receptors are resistant to blockade by xanthine antagonists, but human sheep can be potently blocked certain xanthines, notably acidic 8-phenylxanthines. One function facilitate degranulation mast cells, role for cells mediating myocardial preconditioning has been proposed. Therefore, selective antagonists have potential treatment allergic, inflammatory possibly ischaemic disorders.
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