Systemic Antiangiogenic Therapy for Choroidal Neovascularization

摘要: In 1991, it was reported that interferon alfa an effective treatment in some cases of choroidal neovascularization secondary to age-related macular degeneration.1We will review the scientific rationale for this treatment, and suggest may be too early recommend general use these ocular diseases until its efficacy safety are further demonstrated. See also p 1366. Interferon has been used hairy-cell leukemia other neoplastic since 1984.2Recent experimental studies laboratory clinic have revealed a new property interferon, ability inhibit angiogenesis.3-8Angiogenesis, growth capillary blood vessels, is fundamental process reproduction, development, repair.9Under normal conditions such as ovulation, brief tightly controlled. However, pathologic angiogenesis, neovascularization, psoriasis, hemangiomas, cancer, can prolonged serve