circRNA meets gene amplification.

作者: Nicholas Manguso , Armando E. Giuliano , Hisashi Tanaka

DOI: 10.21037/NCRI.2018.06.04

关键词: MedicineGene duplicationCancer researchCancerLungAdenocarcinomaLung cancerDisease

摘要: Lung cancer remains the most common cause of related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of different types lung cancer, adenocarcinoma (LAC) is (2). Given prevalence lethality need to elucidate mechanisms this disease develop novel therapeutic targets paramount. The understanding biology genetics LAC essential learning more about disease.

参考文章(17)
Thomas B Hansen, Trine I Jensen, Bettina H Clausen, Jesper B Bramsen, Bente Finsen, Christian K Damgaard, Jørgen Kjems, None, Natural RNA circles function as efficient microRNA sponges Nature. ,vol. 495, pp. 384- 388 ,(2013) , 10.1038/NATURE11993
Paul Bertone, Viktor Stolc, Thomas E Royce, Joel S Rozowsky, Alexander E Urban, Xiaowei Zhu, John L Rinn, Waraporn Tongprasit, Manoj Samanta, Sherman Weissman, Mark Gerstein, Michael Snyder, Global Identification of Human Transcribed Sequences with Genome Tiling Arrays Science. ,vol. 306, pp. 2242- 2246 ,(2004) , 10.1126/SCIENCE.1103388
Verline Justilien, Michael P. Walsh, Syed A. Ali, E. Aubrey Thompson, Nicole R. Murray, Alan P. Fields, The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma Cancer Cell. ,vol. 25, pp. 139- 151 ,(2014) , 10.1016/J.CCR.2014.01.008
Jian-hua Yin, Guang-wen Cao, Wei-ping Zhou, Fang Wang, Shu-han Sun, Chuan-chuan Zhou, Fu Yang, Sheng-xian Yuan, Jin-zhao Ma, Feng Liu, Ji-hang Yuan, Feng-rui Bi, Kong-ying Lin, Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. Hepatology. ,vol. 63, pp. 850- 863 ,(2016) , 10.1002/HEP.28393
Xiaoyang Zhang, Peter S Choi, Joshua M Francis, Marcin Imielinski, Hideo Watanabe, Andrew D Cherniack, Matthew Meyerson, Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers Nature Genetics. ,vol. 48, pp. 176- 182 ,(2016) , 10.1038/NG.3470
William W. Du, Weining Yang, Elizabeth Liu, Zhenguo Yang, Preet Dhaliwal, Burton B. Yang, Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 Nucleic Acids Research. ,vol. 44, pp. 2846- 2858 ,(2016) , 10.1093/NAR/GKW027
Jone Mitxelena, Aintzane Apraiz, Jon Vallejo-Rodríguez, Marcos Malumbres, Ana M. Zubiaga, E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation Nucleic Acids Research. ,vol. 44, pp. 5557- 5570 ,(2016) , 10.1093/NAR/GKW146
Qiupeng Zheng, Chunyang Bao, Weijie Guo, Shuyi Li, Jie Chen, Bing Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He, Shenglin Huang, Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs Nature Communications. ,vol. 7, pp. 11215- 11215 ,(2016) , 10.1038/NCOMMS11215
Jie Chen, Yan Li, Qiupeng Zheng, Chunyang Bao, Jian He, Bin Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi, Shenglin Huang, Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters. ,vol. 388, pp. 208- 219 ,(2017) , 10.1016/J.CANLET.2016.12.006