Efficient intramolecular cyclizations of phenoxyethynyl diols into multisubstituted α,β-unsaturated lactones.
作者： Masahiro Egi , Yuya Ota , Yuka Nishimura , Kaori Shimizu , Kenji Azechi
DOI: 10.1021/OL401824V
关键词: Intramolecular cyclization 、 Chemistry 、 Intramolecular force 、 Organic chemistry 、 Stoichiometry
摘要: AgOTf-catalyzed intramolecular cyclization of phenoxyethynyl diols proceeded under mild conditions to afford the multisubstituted α,β-unsaturated-γ-lactones in 55–98% yields. This method was also applicable synthesis α,β-unsaturated-δ-lactones. A similar when AgOTf replaced with a stoichiometric amount N-bromosuccinimide furnish α-bromo-substituted α,β-unsaturated lactones.
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