Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma
作者： Han-Mo Koo , George Vande Woude
DOI:
关键词: Proteases 、 In vitro 、 MAPK/ERK pathway 、 Cytotoxic T cell 、 Apoptosis 、 Mitogen-activated protein kinase 、 Chemistry 、 In vivo 、 Cancer research 、 Melanoma
摘要: Inhibitors of the MAPK pathway, including MEK-directed proteases and small molecule inhibitors, are cytotoxic to human melanoma cells in vitro vivo via apoptotic mechanisms. These compounds used kill treat subjects with melanoma, either alone or combination other therapeutic modalities.
lens.org 参考文章(34)
Stephen H. Leppla, Peter J. Nichols, Kurt R. Klimpel, Yogendra Singh, Naveen Arora, Anthrax toxin fusion proteins and related methods ,(1993)
Naveen Arora, Site directed mutagenesis of histidine residues in anthrax toxin lethal factor binding domain reduces toxicity Molecular and Cellular Biochemistry. ,vol. 177, pp. 7- 14 ,(1997) , 10.1023/A:1006815306876
Gary L. Johnson, MEKK protein, capable of phosphorylating MEK ,(1993)
W. Gregory Alvord, Kenneth D. Paull, Mary Jane McWilliams, Larry V. Rubinstein, Anne Monks, Adi F. Gazdar, Herbert K. Oie, Helmut Zarbl, Helmut Zarbl, Han Mo Koo, George F. Vande Woude, Marcia Gray-Goodrich, Andrei M Mikheev, Andrei M Mikheev, Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes Cancer Research. ,vol. 56, pp. 5211- 5216 ,(1996)
Haile Tecle, Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors ,(1999)
Stephen Leppla, Nicholas Duesbery, Craig Webb, George Vande Woude, Anthrax lethal factor is a MAPK kinase protease ,(1999)
Alex Hajnal, Roman Klemenz, Reinhold Schäfer, Suppression of ras-mediated transformation: Differential expression of genes encoding extracellular matrix proteins in normal, transformed and revertant cells Advances in Enzyme Regulation. ,vol. 33, pp. 267- 272 ,(1993) , 10.1016/0065-2571(93)90023-7
Kurt R. Klimpel, Peter J. Nicholls, Stephen H. Leppla, Yogendra Singh, Naveen Arora, Anthrax toxin fusion proteins, nucleic acid encoding same ,(1993)
Keith Hopkinson Gibson, Quinoline derivatives as inhibitors of mek enzymes ,(2000)
Alan Robert Saltiel, Alexander James Bridges, 2-(2-amino-3-methoxyphenyl)-4-oxo-4h-[1]benzopyran for treating proliferative disorders ,(1995)