ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions.

摘要: Ligands for ErbB receptors, including epidermal growth factor (EGF) and neuregulin-1, have a neurotrophic activity on midbrain dopaminergic neurons are implicated in the pathophysiology of schizophrenia. Although kinase inhibitors ameliorate behavioral deficits schizophrenia model that was established by hippocampal lesioning rat pups, antipsychotic action its general applicability to other models not fully characterized. Using different animal model, here, we examined whether how endophenotypes relevant The prepared exposing neonatal rats cytokine EGF. Intraventricular infusion ErbB1 ZD1839 PD153035 these animals ameliorated startle response prepulse inhibition dose-dependent manner. latent fear learning were also alleviated with limited effects body weight gain or locomotor activity. decreased busting nigral dopamine (DA) reduced pallidal DA metabolism, result mimics anti-dopaminergic profile risperidone haloperidol this brain region. appear actions alleviate some common