The prognostic value of lymphatic and blood vessel invasion in operable breast cancer

摘要: Background. This study assessed the prognostic effect of lymphatic and blood vessel invasion (LVI BVI) on survival in a retrospective sample 1408 patients with breast cancer. Methods. Survival analysis was evaluated by univariate (Kaplan-Meier product limit method log rank test) multivariate (Cox model) analysis. Correlations among variables were studied contingency tables statistical significance chi-square test. Results. Lymphatic present 34.2% cases, BVI 4.2%. correlated (P < 0.0001), both metastatic axillary lymph nodes increasing tumor size grade; sporadic (only 10 cases) node negative patients. Although LVI more frequent premenopausal those ductal carcinomas, unrelated to menopausal status type. associated poor 0.0001). By analysis, relative risk death significantly increased when whole series as well positive subgroups; role independent status, size, grade, or adjuvant treatment. In sample, had strong power. also number metastases. Blood no any subgroup. Conclusion. The prevalence particularly low this study, question its possible for cancer should be methods that amplify detection. is factor operable cancer. patients, predictor prognosis who are consequently candidates therapy. Similarly, high highly intensive strategies. Cancer 1995; 76:1772–8.