The carcinogenicity of metals in humans.

摘要: Epidemiologic evidence on the relation between exposure to metals and cancer is reviewed. Human common, with wide use in industry long-term environmental persistence. Historically, heaviest metal exposures occurred workplace or settings close proximity industrial sources. Among general population, a number of widespread but generally at substantially lower levels than have been found industry. The carcinogenicity arsenic, chromium, nickel has established. Occupational arsenic linked increased lung risk humans, although experimental studies remain inconclusive. Experimental clearly demonstrate malignant potential hexavalent (VI) chromium compounds, solubility being an important determining factor. workers chemical production link nasal cancer. epidemiologic data show that sparingly-soluble compounds possibly also soluble are carcinogens humans. Some suggest lead may be human carcinogen, Although less extensive for beryllium cadmium, findings humans excess supported by clear demonstration studies. Other metals, including antimony cobalt, maybe carcinogens, limited.