Epigenetic Changes in Cancer: Role of Environment
作者： Zdenko Herceg , Paolo Boffetta
DOI: 10.1007/978-1-4419-6752-7_7
关键词: Cancer research 、 DNA repair 、 Cancer 、 Epigenetics 、 Bioinformatics 、 Cancer cell 、 Cancer prevention 、 Carcinogenesis 、 DNA methylation 、 Heredity 、 Biology
摘要: It is now recognized that epigenetic heredity important for understanding the causes of complex diseases such as cancer. Recent discoveries provided strong evidence arguing mechanisms play key roles in virtually all stages cancer development and progression. A number critical processes found cells, silencing tumour suppressor genes, activation oncogenes, aberrant cell cycle, defects DNA repair, can be a consequence not only genetic but also changes. Various environmental agents are either known or suspected risk factors human may promote tumorigenesis by eliciting Better contribution induced environment prove novel strategies prevention.
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Audrey S. Baur, Phil Shaw, Nathalie Burri, Françoise Delacrétaz, Fred T. Bosman, Pascal Chaubert, Frequent methylation silencing of p15INK4b (MTS2) and p16INK4a (MTS1) in B-cell and T-cell lymphomas Blood. ,vol. 94, pp. 1773- 1781 ,(1999) , 10.1182/BLOOD.V94.5.1773
A. Aoike, N. Ohtani-Fujita, T. Sakai, Paul D Robbins, T. Fujita, N. E. Osifchin, CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene Oncogene. ,vol. 8, pp. 1063- 1067 ,(1993)
Naohito Kanazumi, Kenji Hibi, Mitsuru Sakai, Shuji Nomoto, Akimasa Nakao, Soichiro Inoue, Shin Takeda, Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma. Hepato-gastroenterology. ,vol. 52, pp. 1854- 1857 ,(2005)
ERNEST L. WYNDER, Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. JAMA. ,vol. 143, pp. 329- 336 ,(1950) , 10.1001/JAMA.1950.02910390001001
Richard B. Hayes, The carcinogenicity of metals in humans. Cancer Causes & Control. ,vol. 8, pp. 371- 385 ,(1997) , 10.1023/A:1018457305212
Shui Wang, Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. World Journal of Gastroenterology. ,vol. 10, pp. 1815- 1818 ,(2004) , 10.3748/WJG.V10.I12.1815
John H. Campbell, Penny Perkins, Transgenerational effects of drug and hormonal treatments in mammals: a review of observations and ideas Progress in Brain Research. ,vol. 73, pp. 535- 553 ,(1988) , 10.1016/S0079-6123(08)60525-7
Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen, James G. Herman, Stephen B. Baylin, Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nature Genetics. ,vol. 21, pp. 103- 107 ,(1999) , 10.1038/5047
Peter L. Jones, Gert Jan C. Veenstra, Paul A. Wade, Danielle Vermaak, Stefan U. Kass, Nicoletta Landsberger, John Strouboulis, Alan P. Wolffe, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genetics. ,vol. 19, pp. 187- 191 ,(1998) , 10.1038/561
Hui Li, Janos Minarovits, Host Cell-Dependent Expression of Latent Epstein–Barr Virus Genomes: Regulation by DNA Methylation Advances in Cancer Research. ,vol. 89, pp. 133- 156 ,(2003) , 10.1016/S0065-230X(03)01004-2