Transgenerational effects of drug and hormonal treatments in mammals: a review of observations and ideas

摘要: Publisher Summary This chapter is concerned with disturbances to several neuroendocrine systems of young animals having the following remarkable combination consequences: (1) experimentally treating a animal induces characteristic abnormalities that persist into adulthood, (2) crossing treated males normal females gives offspring altered phenotype, (3) carry over multiple generations, and (4) some transmitted alterations coincide known functions perturbed system or changes treatment induced in parent animal. Transgenerational effects hormone drug exposure lie at intersection genetics physiology have different meanings for two disciplines. Endocrinologists are interested their physiological significance individual general. Hormonal stresses critical periods during development can lead long-lasting, even permanent, adult levels. The existence common carryover mechanism variety an attractive idea.