Preconception Exposure of Males and Neoplasia in their Progeny: Effects of Metals and Consideration of Mechanisms

摘要: Exposures of male rodents, either as fetuses or in the weeks before mating, to X- neutron radiation, an assortment chemical carcinogens (urethane, ethylnitrosourea, 4-nitroquinoline N-oxide, diethylstilbestrol, cyclophosphamide), have resulted significant increases incidences tumors their progeny and sometimes later generations (review Tomatis et al, 1992; see also Francis 1990; Loktionov al.; 1992, Turusov Takahashi 1992). Target organs included nervous system uterus rats, lung, lymphoid tissue, ovary, uterus, liver, intestine mice. females revealed multigenerational carcinogenesis effects, with implication additional compounds (methylnitrosourea, o-aminoazotoluene, 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene, benzo(a)pyrene) target (skin, mammary gland, pituitary). Broad significance phenomenon is suggested by diversity tumorigenic agents causing it wide range organs.