252Cf relative biological effectiveness and inheritable effect of fission neutrons in mouse liver tumorigenesis.

摘要: To determine the relative biological effectiveness of 252Cf fission neutrons versus 60Co γ-rays for inducing liver tumorigenesis, C57BL/6NCrj × C3H/NCrj F1, hereafter called B6C3F1, mice were irradiated once either with or and tumorigenicity two types radiation was studied. Individual groups B6C3F1 (about 30 mice/group) at doses 0, 3, 6, 12.5, 50, 200 cGy males females both sexes. The observed 13 months after irradiation. The incidence hepatic tumors in nonirradiated controls 3.8% 3.2% females. irradiation increased dose dependently females, but less efficiently mean number size well correlated tumor incidence. In contrast, efficient tumors. compared to quite high low-dose range. Overall, average 15.2 2.5 females. In another experiment, 7-week-old male C3H mice, which are known be carriers tumorinogens, that fathers 252Cf, 2 weeks later they mated female C57BL mice. control had fathers. offspring 43% 1.7% whereas 3.3% multiplicity similar incidence. Thus our results indicated a strong hepatocarcinogenic potential γ-rays, cancer-prone genetic trait activated by inherited first-generation offspring, especially males.