Studies on Oxidative Mechanisms of Metal-Induced Carcinogenesis
作者： Kazimierz S. Kasprzak , Wojciech Bal , Dale W. Porter , Karol Bialkowski
DOI: 10.1007/978-1-4615-4865-2_16
关键词:
摘要: Two ways by which carcinogenic metals, such as Ni(II), Co(II), Cu(II), or Cd(II), may promote oxidative DNA damage, including direct effects consisting of activation oxygen species and mediation their attack on DNA, indirect through suppression cellular antimutagenic defenses, are discussed. The mechanisms the involve chelation a metal nuclear proteins, especially histones protamines, metabolic resulting complexes at close proximity to DNA. We found that human protamine HP2 has typical binding motif for Ni(II) Arg-Thr-His-, its N-terminus. A synthetic pentadecapeptide modeling this terminus formed strong chelates with these metals and, in addition, enhanced damage plus H2O2, but suppressed, though not completely, Cu(II) H2O2. Since protamines carry sperm, observed have spermicidal transgenerational man exposed epidemiologically. inhibition 8-oxo-dGTPases, class enzymes preventing incorporation 8-oxoguanine lesion from oxidatively-damaged deoxynucleotide pool into Cd(II) limited extent also were vitro inhibit enzymatic activity bacterial (MutT) (MTH1) 8-oxo dGTPases. This allow redox-inactive introduce promutagenic endogenously damaged 8-oxo-dGTP
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sci-hub.st 参考文章(108)
Lucy M. Anderson, Kazimierz S. Kasprzak, Jerry M. Rice, Preconception Exposure of Males and Neoplasia in their Progeny: Effects of Metals and Consideration of Mechanisms Springer, Boston, MA. pp. 129- 140 ,(1994) , 10.1007/978-1-4615-1877-8_12
K. S. Kasprzak, The Oxidative Damage Hypothesis of Metal-Induced Genotoxicity and Carcinogenesis Springer Netherlands. pp. 73- 92 ,(1997) , 10.1007/978-94-011-5780-3_5
Robert W. Woody, [4] Circular dichroism Methods in Enzymology. ,vol. 246, pp. 34- 71 ,(1995) , 10.1016/0076-6879(95)46006-3
Maureen Paul, Occupational and environmental reproductive hazards : a guide for clinicians Williams & Wilkins. ,(1993)
W. Bal, K. S. Kasprzak, Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3 Springer, Dordrecht. pp. 107- 121 ,(1997) , 10.1007/978-94-011-5780-3_7
P F Predki, C Harford, P Brar, B Sarkar, Further characterization of the N-terminal copper(II)- and nickel(II)-binding motif of proteins. Studies of metal binding to chicken serum albumin and the native sequence peptide. Biochemical Journal. ,vol. 287, pp. 211- 215 ,(1992) , 10.1042/BJ2870211
Jonathan Buckley, Male-Mediated Developmental Toxicity: Paternal Exposures and Childhood Cancer Springer, Boston, MA. pp. 169- 175 ,(1994) , 10.1007/978-1-4615-1877-8_15
Frederick E. Petry, Principles and Applications Kluwer Academic Publishers. ,(1997)
B. Sarkar, Design of Proteins with ATCUN Motif which Specifically Cleave DNA Springer Netherlands. pp. 477- 491 ,(1997) , 10.1007/978-94-011-5780-3_30
László Magos, Thomas W Clarkson, Tsuguyoshi Suzuki, Louis W Chang, Toxicology of metals Published in <b>1996</b> in Boca Raton Fla) by Lewis. ,(1996)