A possible maternal effect in the abnormal hyporesponsiveness to specific alloantigens in offspring born to neonatally tolerant fathers.

摘要: Newborn CBA mice were inoculated i.p. with 1 X 10(8) adult (CBA A)F1 lymphoid cells 5 10(7) F1 hybrid thereafter i.v. at 14-day intervals. The subsequently grafted A/J tail skin 24 days of age. At 8 wk age, individual tolerant males intact grafts each mated similar skin-grafted females or 8-wk-old control normal females. Approximately 0.4 ml peripheral blood from 7-wk-old progeny born to these crosses, along the age-matched incrosses, used for in vitro mixed leukocyte cultures (MLC). All received 7 1/2 In this study, we show i) that MLC hyporesponsiveness histocompatible is an acquired phenotype expressed by male mice, and ii) also delayed rejection grafts. continued breeding first generation animals established a transmission can be observed second progeny. When putatively females, however, which had borne several litters after mating neonatally males, "normal" (nontolerant) males; their offspring exhibited specific initial tolerizing allodeterminants. This suggests there may ultimately maternally derived origin characters males.