Adriamycin Metabolism in Man
作者： Nicholas R. Bachur
DOI: 10.1007/978-1-4613-4349-3_10
关键词: Cancer research 、 Soft tissue sarcoma 、 Myelogenous 、 Breast cancer 、 Acute lymphocytic leukemia 、 Vomiting 、 Daunorubicin 、 Acute leukemia 、 Medicine 、 Lung cancer
摘要: Over the past eight years, adriamycin, outstanding representative of anthracycline antibiotics, has demonstrated a remarkable activity against human and animal malignancies (1,2). Whereas adriamycin’s sibling, daunorubicin, been impressive for remission induction in acute myelogenous lymphocytic leukemias, adriamycin wider spectrum is useful solid tumors. Clinical investigators Europe, Americas, Asia, Africa find anticancer soft tissue sarcomas, breast cancer, lung hepatomas, lymphomas, etc. Against some malignancies, no pharmacologic activity. Complicating usage both daunorubicin are toxic effects: myelosuppression, stomatitis, nausea, vomiting, alopecia, electrocardiographic changes, serious cumulative dosage related myocardiopathy.
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sci-hub.st 参考文章(9)
International Symposium on Adriamycin Springer Berlin Heidelberg. ,(1972) , 10.1007/978-3-642-95227-2
Fred E. Hahn, Progress in Molecular and Subcellular Biology ,(2011)
Ronald L. Felsted, Malcolm Gee, Nicholas R. Bachur, Rat Liver Daunorubicin Reductase AN ALDO-KETO REDUCTASE Journal of Biological Chemistry. ,vol. 249, pp. 3672- 3679 ,(1974) , 10.1016/S0021-9258(19)42527-1
N. R. Bachur, R. S. Jaenke, R. C. Hildebrand, Adriamycin and daunorubicin disposition in the rabbit. Journal of Pharmacology and Experimental Therapeutics. ,vol. 191, pp. 331- 340 ,(1974)
LIONEL E. MAWDESLEY-THOMAS, Research into Fish Diseases Nature. ,vol. 235, pp. 17- 19 ,(1972) , 10.1038/235017A0
Jacqueline Whang-Peng, Brigid G. Leventhal, John W. Adamson, Seymour Perry, The effect of daunomycin on human cells in vivo and in vitro Cancer. ,vol. 23, pp. 113- 121 ,(1969) , 10.1002/1097-0142(196901)23:1<113::AID-CNCR2820230113>3.0.CO;2-F
Nicholas R. Bachur, Robert C. Hildebrand, Merrill J. Egorin, Eugene F. Cimino, Cytofluorescence Localization of Adriamycin and Daunorubicin Cancer Research. ,vol. 34, pp. 2243- 2245 ,(1974)
Nicholas R. Bachur, Malcolm Gee, DAUNORUBICIN METABOLISM BY RAT TISSUE PREPARATIONS Journal of Pharmacology and Experimental Therapeutics. ,vol. 177, pp. 567- 572 ,(1971)
W D Meriwether, N R Bachur, Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia. Cancer Research. ,vol. 32, pp. 1137- 1142 ,(1972)