Pharmacokinetics of liposomal doxorubicin (TLC-D99; Myocet) in patients with solid tumors: an open-label, single-dose study
作者： Klaus Mross , Bernward Niemann , Ulrich Massing , Joachim Drevs , Clemens Unger
DOI: 10.1007/S00280-004-0825-Y
关键词:
摘要: Purpose Liposomal encapsulation of doxorubicin is designed to increase safety and tolerability by decreasing cardiac gastrointestinal toxicity through decreased exposure these tissues doxorubicin, while effectively delivering drug the tumor. We conducted an open-label phase I study determine pharmacokinetic profile a single dose liposome-encapsulated (Myocet) in patients with various solid tumors. Safety were monitored.
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