Doxorubicin-Induced Cardiomyopathy
作者： Pawan K. Singal , Natasha Iliskovic
DOI: 10.1056/NEJM199809243391307
关键词: Sarcoma 、 Doxorubicin 、 Cancer research 、 Heart disease 、 Cardiomyopathy 、 Medicine 、 Osteosarcoma 、 Drug 、 Cancer 、 Pathology 、 Pharmacokinetics
摘要: Doxorubicin (Adriamycin) has been used in oncologic practice since the late 1960s. It held promise as a powerful drug fight against cancer. The tumors most commonly responding to doxorubicin when it is given single agent or combination with other antitumor agents include breast and esophageal carcinomas; osteosarcoma, Kaposi's sarcoma, soft-tissue sarcomas; Hodgkin's non-Hodgkin's lymphomas. Other cancers that are less responsive but still treated because of its overall benefits gastric, liver, bile-duct, pancreatic, endometrial carcinomas. However, reports fatal cardiotoxic effects have . . .
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