Gene inhibition using antisense oligodeoxynucleotides.
DOI: 10.1038/372333A0
关键词: Antisense DNA 、 Molecular biology 、 Antisense odns 、 Biology 、 Antisense oligodeoxynucleotides 、 Genetic enhancement 、 Cancer research 、 Gene expression 、 Gene
摘要: … to address questions about gene function and may also lead … Inhibition of gene expression by antisense ODNs relies on … antisense ODNs can cause specific inhibition of target genes, …
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W.B. Offensperger, S. Offensperger, E. Walter, K. Teubner, G. Igloi, H.E. Blum, W. Gerok, In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides. The EMBO Journal. ,vol. 12, pp. 1257- 1262 ,(1993) , 10.1002/J.1460-2075.1993.TB05767.X
ELIEL BAYEVER, PATRICK L. IVERSEN, MICHAEL R. BISHOP, J. GRAHAM SHARP, HEMANT K. TEWARY, MARK A. ARNESON, SAMUEL J. PIRRUCCELLO, RAYMOND W. RUDDON, ANNE KESSINGER, GERALD ZON, JAMES O. ARMITAGE, Systemic Administration of a Phosphorothioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I Trial Antisense research and development. ,vol. 3, pp. 383- 390 ,(1993) , 10.1089/ARD.1993.3.383
L. Yakubov, Z. Khaled, L.M. Zhang, A. Truneh, V. Vlassov, C.A. Stein, Oligodeoxynucleotides interact with recombinant CD4 at multiple sites. Journal of Biological Chemistry. ,vol. 268, pp. 18818- 18823 ,(1993) , 10.1016/S0021-9258(17)46701-9
A. Amaratunga, P.J. Morin, K.S. Kosik, R.E. Fine, Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleotide. Journal of Biological Chemistry. ,vol. 268, pp. 17427- 17430 ,(1993) , 10.1016/S0021-9258(19)85352-8
R. McKay, T.P. Condon, N.M. Dean, C.F. Bennett, Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. Journal of Biological Chemistry. ,vol. 269, pp. 16416- 16424 ,(1994) , 10.1016/S0021-9258(17)34023-1
I Kitajima, T Shinohara, T Minor, L Bibbs, J Bilakovics, M Nerenberg, Human T-cell leukemia virus type I tax transformation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo. Journal of Biological Chemistry. ,vol. 267, pp. 25881- 25888 ,(1992) , 10.1016/S0021-9258(18)35691-6
B.P. Monia, E.A. Lesnik, C. Gonzalez, W.F. Lima, D. McGee, C.J. Guinosso, A.M. Kawasaki, P.D. Cook, S.M. Freier, Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression Journal of Biological Chemistry. ,vol. 268, pp. 14514- 14522 ,(1993) , 10.1016/S0021-9258(19)85268-7
M.Y. Chiang, H. Chan, M.A. Zounes, S.M. Freier, W.F. Lima, C.F. Bennett, Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. Journal of Biological Chemistry. ,vol. 266, pp. 18162- 18171 ,(1991) , 10.1016/S0021-9258(18)55250-9
S. Grimm, H. Chan, T. P. Condon, C. F. Bennett, Ming-Yi Chiang, Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. Journal of Immunology. ,vol. 152, pp. 3530- 3540 ,(1994)
B. Weiss, Long-Wu Zhou, Sui-Po Zhang, Zheng-Hong Qin, In vivo administration of an oligodeoxynucleotide antisense to the D2 dopamine receptor messenger RNA inhibits D2 dopamine receptor-mediated behavior and the expression of D2 dopamine receptors in mouse striatum. Journal of Pharmacology and Experimental Therapeutics. ,vol. 268, pp. 1015- 1023 ,(1994)