Prevention of peritendinous adhesions using an electrospun DegraPol polymer tube: a histological, ultrasonographic, and biomechanical study in rabbits

作者: Gabriella Meier Bürgisser , Maurizio Calcagni , Angela Müller , Eliana Bonavoglia , Gion Fessel

DOI: 10.1155/2014/656240

关键词: SurgeryMedicineHindlimbWound healingAchilles tendonTendonSuture (anatomy)Tissue AdhesionUltrasoundAdhesion (medicine)

摘要: Purpose. One of the great challenges in surgical tendon rupture repair is to minimize peritendinous adhesions. In order reduce adhesion formation, a physical barrier was applied sutured rabbit Achilles tendon, with two different immobilization protocols used postoperatively. Methods. Thirty New Zealand white rabbits received laceration on 4-strand Becker suture, and half got DegraPol tube at site. While fifteen had their treated hind leg 180° stretched position during 6 weeks (adhesion provoking immobilization), other were recasted 150° after 3 inhibiting immobilization). Adhesion extent analysed macroscopically, via ultrasound histology. Inflammation determined histologically. Biomechanical properties analysed. Results. Application reduced formation by approximately 20%—independently protocol. extracted specimen not affected application. There no serious inflammatory reaction towards implant material. Conclusions. Implantation tightly set around acts as beneficial prevents significantly—without affecting healing process.

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