Auto-crosslinked hyaluronic acid gel accelerates healing of rabbit flexor tendons in vivo.
作者： Thijs de Wit , Dennis de Putter , Wendy M.W. Tra , Hinne A. Rakhorst , Gerjo J.V.M. van Osch
DOI: 10.1002/JOR.20730
关键词:
摘要: This study's purpose was to assess the in vivo effect of auto-crosslinked hyaluronic acid (HA) gel, a natural HA derivative with increased viscosity and tissue residence time, on adhesions healing injured surgically repaired rabbit digital flexor tendons. The second third right deep tendons from 48 rabbits (n = 96 tendons) were cut modified Kessler running peripheral suture. Animals randomized two groups, receiving either gel or saline injected around both freshly After 2, 3, 6, 12 weeks, six each group euthanized. Tendon pull-out force breaking strength measured as value for adhesion formation tendon healing, respectively. A histological assessment related mechanical results. significantly faster increase found gel-treated compared saline-treated tendons; this coincided accelerated repair response after injury. No significant difference between groups at any time. Our results indicate acceleration treated gel. Adhesion unaffected. These could have important clinical promoting rehabilitation
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