The Effect of Phospholipids (Surfactant) on Adhesion and Biomechanical Properties of Tendon: A Rat Achilles Tendon Repair Model
作者： T. Kursat Dabak , Omer Sertkaya , Nuray Acar , B. Ozgur Donmez , Ismail Ustunel
DOI: 10.1155/2015/689314
关键词: Tendon 、 Adhesion 、 Surgery 、 Tissue Adhesion 、 Biomechanical Phenomena 、 Achilles tendon 、 Wound healing 、 Biomedical engineering 、 Hyaluronic acid 、 Phospholipid 、 Chemistry
摘要: Adhesion of the tendon is a major challenge for orthopedic surgeon during repair. Manipulation biological environment one concepts to prevent adhesion. Lots biochemicals have been studied this purpose. We aimed determine effect phospholipids on adhesion and biomechanical properties in an animal repair model. Seventy-two Wistar rats were divided into 4 groups. Achilles tendons cut repaired. Phospholipids applied at two different dosages. Tendon was determined histopathologically test performed. At macroscopic evaluation adhesion, there are statistically significant differences between multiple-dose phospholipid injection group Control also hyaluronic acid (p 0.008). Ultimate strength highest lowest group. Single-dose (surfactant) application may beneficial Although multiple applications seem most effective regime reduce among groups, it deteriorated tendon.
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