Adhesion reduction after knee surgery in a rabbit model by Hyaloglide, a hyaluronan derivative gel.
作者： G. Brunelli , C. Longinotti , C. Bertazzo , A. Pavesio , D. Pressato
DOI: 10.1016/J.ORTHRES.2005.05.001.1100230620
关键词: Rabbit model 、 Adhesion (medicine) 、 Arthrofibrosis 、 Knee surgery 、 Kirschner wire 、 Hyaloglide 、 Reduction (orthopedic surgery) 、 Scoring system 、 Medicine 、 Surgery
摘要: A randomized controlled experimental trial was performed in a rabbit model of surgical adhesions to investigate the anti-adhesive effects Hyaloglide®, highly viscous hyaluronan derivative absorbable gel after knee surgery. Twenty New Zealand white rabbits were prepared and randomly divided into two groups 10 animals each. An intra-articular fibro-adhesive scar created right joint hind paw each using standardized procedure, Hyaloglide® administered cavity at end intervention belonging treatment group. No applied control Additionally, immobilization Kirschner wire order increase risk adhesions. Six weeks surgery euthanized removal system, evaluated both macroscopically histologically. Results gross observations specific adhesion scoring system showed significant reduction (p < 0.01) incidence severity hyaluronan-treated group compared Histologically, treated thinner with less collagenic fibers. In conclusion, may be considered as promising barrier for prevention post-operative fibrotic
sci-hub.se 参考文章(46)
Claudio Belluco, Fabrizio Meggiolaro, Daniele Pressato, Alessandra Pavesio, Emilio Bigon, Massimo Donà, Marco Forlin, Donato Nitti, Mario Lise, Prevention of postsurgical adhesions with an autocrosslinked hyaluronan derivative gel Journal of Surgical Research. ,vol. 100, pp. 217- 221 ,(2001) , 10.1006/JSRE.2001.6248
M. MENTZEL, H. HOSS, P. KEPPLER, T. EBINGER, L. KINZL, N. J. WACHTER, The effectiveness of ADCON-T/N, a new anti-adhesion barrier gel, in fresh divisions of the flexor tendons in Zone II. Journal of Hand Surgery (European Volume). ,vol. 25, pp. 590- 592 ,(2000) , 10.1054/JHSB.2000.0385
Colin L. Eakin, Knee Arthrofibrosis The Physician and Sportsmedicine. ,vol. 29, pp. 31- 42 ,(2001) , 10.3810/PSM.2001.03.668
James W. Burns, Kevin Skinner, Jude Colt, Aviva Sheidlin, Roderick Bronson, Yoseph Yaacobi, Eugene P. Goldberg, Prevention of Tissue Injury and Postsurgical Adhesions by Precoating Tissues with Hyaluronic Acid Solutions Journal of Surgical Research. ,vol. 59, pp. 644- 652 ,(1995) , 10.1006/JSRE.1995.1218
Naoshi Fukui, Kohei Nakajima, Toshiyuki Tashiro, Hiromi Oda, Kozo Nakamura, Neutralization of fibroblast growth factor-2 reduces intraarticular adhesions. Clinical Orthopaedics and Related Research. ,vol. 383, pp. 250- 258 ,(2001) , 10.1097/00003086-200102000-00029
Lars Hagberg, Exogenous hyaluronate as an adjunct in the prevention of adhesions after flexor tendon surgery : A controlled clinical trial Journal of Hand Surgery (European Volume). ,vol. 17, pp. 132- 136 ,(1992) , 10.1016/0363-5023(92)90128-C
Pier Andrea De Laco, Marco Stefanetti, Daniele Pressato, Simonetta Piana, Massimo Donà, Alessandra Pavesio, Luciano Bovicelli, A novel hyaluronan-based gel in laparoscopic adhesion prevention: preclinical evaluation in an animal model Fertility and Sterility. ,vol. 69, pp. 318- 323 ,(1998) , 10.1016/S0015-0282(98)00496-8
M. Mensitieri, L. Ambrosio, L. Nicolais, D. Bellini, M. O'Regan, VISCOELASTIC PROPERTIES MODULATION OF A NOVEL AUTOCROSSLINKED HYALURONIC ACID POLYMER Journal of Materials Science: Materials in Medicine. ,vol. 7, pp. 695- 698 ,(1996) , 10.1007/BF00123409
Julie A Miller, Ronney L Ferguson, Dennis L Powers, James W Burns, Shalaby W Shalaby, None, Efficacy of hyaluronic acid/nonsteroidal anti-inflammatory drug systems in preventing postsurgical tendon adhesions. Journal of Biomedical Materials Research. ,vol. 38, pp. 25- 33 ,(1997) , 10.1002/(SICI)1097-4636(199721)38:1<25::AID-JBM4>3.0.CO;2-J
Douglas M. Rothkopf, Sharon Webb, Robert M. Szabo, Richard H. Gelberman, James W. May, An experimental model for the study of canine flexor tendon adhesions. Journal of Hand Surgery (European Volume). ,vol. 16, pp. 694- 700 ,(1991) , 10.1016/0363-5023(91)90196-I