Morphologic lesions and acute toxicity in rainbow trout (Salmo Gairdneri) treated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
作者： Jan M. Spitsbergen , James M. Kleeman , Richard E. Peterson
DOI: 10.1080/15287398809531119
关键词: Juvenile 、 Acute toxicity 、 Thymic involution 、 Salmo 、 Rainbow trout 、 Tetrachlorodibenzo-p-dioxin 、 Physiology 、 Hypocellularity 、 Toxicity 、 Chemistry 、 Toxicology
摘要: To determine effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) on growth, mortality, and morphologic lesions in rainbow trout, juvenile Shasta or Wytheville strain fish, obtained from 4 hatcheries, were administered graded single doses TCDD, 0.1–125 μg/kg, ip. TCDD 25 125 μg/kg caused 85% lethality 2–4 wk after treatment. At these high doses, death occurred before body weight loss could be detected. A lower dose 5 decreased growth cumulative mortality 20% 11 wk. Stress associated with netting weighing the fish at weekly intervals significantly shortened delay period prior to TCDD‐induced lethality. Gross microscopic evident trout treated 10 μg TCDD/kg, but not 1 0.1 μg/kg. Morphologic consistently epithelial lymphomyeloid tissues TCDD‐treated fish. Lymphomyeloid included thymic involution, splenic lymphoid depletion, hypocellularity hematopoietic tissu...
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