Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction.

摘要: Abstract Background Learned fear is crucial in the development and maintenance of posttraumatic stress disorder other anxiety disorders, extinction learned necessary for response to exposure-based treatments. In humans, research suggests that disrupted sleep impairs consolidation extinction, though no studies have examined this experimentally using total deprivation. Methods Seventy-one healthy control subjects underwent a paradigm acquire conditioned visual cue. Twenty-four hours after conditioning, participants learning. learning, recall. Participants were randomized three groups: 1) well-rested throughout testing ("normal sleep"; n = 21); 2) 36 hours' deprivation before learning ("pre-extinction deprivation"; 25); or 3) recall ("post-extinction 25). The groups compared on blink electromyography reactivity condition stimulus during Results There differences among During recall, pre-extinction group demonstrated significantly less than normal did. was significant difference between post-extinction indicated training disrupts Conclusions These findings suggest immediate aftermath trauma could be potential contributor via interference with natural processes management symptoms should considered extinction-based therapy.