Targeting the Bcl-2
作者： Mehul P Patel , Aisha Masood , Priya S Patel , Asher A Chanan-Khan
DOI: 10.1097/CCO.0B013E328331A7A4
关键词: Drug resistance 、 Medicine 、 Apoptosis 、 Text mining 、 Small molecule 、 Cancer research 、 Cancer 、 Protein overexpression 、 Intrinsic apoptotic pathway
摘要: Purpose of reviewMembers the Bcl-2 family proteins are critical components in regulating intrinsic apoptotic pathway. protein overexpression is associated with drug resistance and poor clinical outcome cancer patients. Preclinical evaluations demonstrate that downregu
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