In vivo Role of Cytochrome P450 2E1 and Glutathione-S-Transferase Activity for Acrylamide Toxicokinetics in Humans
作者： Oxana Doroshyenko , Uwe Fuhr , Daria Kunz , Dorothee Frank , Martina Kinzig
DOI: 10.1158/1055-9965.EPI-08-0832
关键词: Pharmacology 、 CYP2E1 、 Biochemistry 、 Acrylamide 、 Glutathione 、 Metabolism 、 Chlorzoxazone 、 In vivo 、 Carcinogen 、 Chemistry 、 Toxicokinetics
摘要: Acrylamide, a potential food carcinogen in humans, is biotransformed to the epoxide glycidamide in vivo. Both acrylamide and glycidamide are conjugated with glutathione …
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