Therapeutic implications of the serotonin transporter gene in depression

摘要: Abstract Background A natural variant of the serotonin transporter gene has been studied in mood disorders and its treatment with inhibitors. It is now available on testing profiles to help guide treatment. But actual interpretation data regarding clinical actionable items controversial. Methods review undertaken understand role short form biology brain effect depression response serotoninergic antidepressants. Results There are naturally occurring variants reuptake (SERT) that express approximately 50 % fewer SERT units synapse. People these low-expressing (frequently referred as ‘short form’) more likely to: 1) develop setting adversity; 2) attempt or re-attempt suicide; 3) respond inadequately an antidepressant; 4) side effects when taking 5) rapid cycling if they have bipolar illness. Emerging suggest due similarity between mechanism action most antidepressants, chronic use antidepressants may significantly worsen consequences patients induce similar outcomes people do not variants. Conclusions Greater caution required exposure inhibitors (or serotonin/norepinephrine inhibitors) for low expressing SERT.