The Vasopressin-Deficient Brattleboro Rat: Lessons for the Hypothalamo–Pituitary–Adrenal Axis Regulation

摘要: Adaptation to stress is indispensable life and the hypothalamo–pituitary–adrenocortical axis one of major components adaptation. The hypothalamic component consists corticotropin-releasing hormone arginine vasopressin, with a questionable contribution latter. Vasopressin was more important in regulation adrenocorticotropin secretion perinatal vasopressin-deficient Brattleboro rats than adulthood, where its role depended on nature stressor encountered. In adults, vasopressin deficiency did not influence development chronic response. neonatal rats, supported by inhibitory action V1b antagonist antiserum. As corticosterone response follow levels, we assume presence an independent adrenal gland neonates. We have shown that apparent dissociation responses due different time course two responses, level binding globulin or changes sensitivity. vitro experiments point beta-adrenoceptors process. It also confirmed vivo tests using pup as model organism, levels may rise without changes. Another question beyond regulation, which could be supposed, e.g., cardiovascular events, immunological processes, metabolism. can conclude gave us much information about stress-axis far itself.