Nanoparticles of chitosan and hyaluronan for the administration of active molecules
作者： Maria De la Fuente Freire , Maria Begona Seijo Rey , Ana Isabel Vila Pena , Ma Jose Alonso Fernandez
DOI:
关键词: Molecule 、 Chitosan 、 Materials science 、 Combinatorial chemistry 、 Nanoparticle 、 Polynucleotide 、 Nanotechnology
摘要: The present invention relates to a nanoparticulate system useful for the delivery of pharmacologically active molecules, and especially transfecting polynucleotides into cells. It comprises nanoparticles chitosan low molecular weight hyaluronan.
lens.org 参考文章(13)
Jörg Ozegowski, Matthias Hilliger, Gundela Peschel, Stephanie Möller, Peter-Jürgen Müller, Hans-Georg Kastner, Biocompatible composite material for medical applications ,(2001)
La Fuente Freire Maria De, Rey Maria Begona Seijo, Fernandez Maria Jose Alonso, Hyaluronic acid nanoparticles ,(2004)
Isabelle Bonnet, Eric Perrier, Chantal Buffevant, Marie-Christine Levy, Particles of cross-linked proteins and polysaccharides with hydroxamic groups for chelating metals and their uses notably in cosmetics ,(1998)
Eva Anne Turley, Samuel Simon Asculai, Use of hyaluronan in gene therapy ,(1996)
Lisbeth Illum, Peter Watts, Drug delivery composition for the nasal administration of antiviral agents ,(1995)
Lisbeth Illum, A drug composition with microspheres and process for its preparation ,(1988)
S.T. Lim, G.P. Martin, D.J. Berry, M.B. Brown, Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. Journal of Controlled Release. ,vol. 66, pp. 281- 292 ,(2000) , 10.1016/S0168-3659(99)00285-0
Aurelio Romeo, Lanfranco Callegaro, Luca Benedetti, Process for the preparation of microspheres containing biologically active components ,(1992)
Russell J. Mumper, Alain Rolland, Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell ,(1997)
Christine Chaumont, Valérie Polard, Andrei Maksimenko, Malam Aboubakar, Targeting system comprising uniformly-sized nanoparticles with at least one polymer and at least one positively-charged polysaccharide and preparation method thereof ,(2003)