Polymeric nanoparticles by ion-ion Interactions
作者： Janos Borbely , Magdolna Bodnar , John F. Hartmann , Istvan Hajdu
DOI:
关键词: Active ingredient 、 Materials science 、 Oligonucleotide 、 Macromolecule 、 Drug carrier 、 Nucleic acid 、 Nanotechnology 、 RNA 、 Nanoparticle 、 Small interfering RNA
摘要: The present invention relates to biocompatible and biodegradable stimuli-sensitive polymeric nanoparticles, which were formed by ion-ion interaction in aqueous media. Synthetic biological macromolecules with ionizable functional groups are capable of forming nanoparticles whose size surface properties sensitive environmental influences such as pH, temperature salt concentration. Nanodevices designed for therapeutic applications drug nucleic acid carriers, and/or MRI diagnosis contrast agents. These nanodevices targeted carriers. Additionally, they can be used agents diagnosis. nanosystems also potential carriers delivery active ingredients DNA, RNA, short interfering RNA (siRNA), antisense oligonucleotides (AS-ON), triple helix (TFO) etc. pharmaceutical applications. Their adjustable offers yet another advantage.
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