Cytoplasmic calcium levels and membrane fluidity of platelets in contact with polyether-polyamide multiblock-copolymer surfaces
作者： Nobuhiko Yui , Teruo Okano , Yasuhisa Sakurai , Shinichi Kora , Kenji Ishikawa
DOI: 10.1111/J.1525-1594.1996.TB00709.X
关键词: Plasticizer 、 Platelet 、 Fura-2 、 Membrane fluidity 、 Platelet activation 、 Polyvinyl chloride 、 Calcium 、 Biophysics 、 Polyamide 、 Chemistry 、 Chromatography
摘要: Cytoplasmic calcium levels and the membrane fluidity of rabbit platelets stored in mini blood bags crystalline-amorphous microstructured polymers (polyether-polyamide multiblock-copolymers) were studied. Fluorescent dye (Fura 2 or 1,6-diphenyl-1,3,5-hexatriene)-loaded platelet suspensions at 37 degrees C for 1 h bags, metabolic changes during storage evaluated by fluorescent spectroscopic technique. The surfaces poly(vinyl chloride) polyolefin elastomers, which are used commercially available enhanced progress metabolism; i.e., there was a dramatic decrease an increase [Ca2+]i. Furthermore, observed prior to These results suggest that contact with polymer can be dominant stage activation these platelets. In contrast, polyether-polyamide multiblock-copolymers exhibited few either [Ca2+]i levels. copolymer inert inactivated terms prevention fluidity.
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