Statin Pleiotropy Against Renal Injury

摘要: Statins may exhibit significant renoprotective effects beyond their lipid-lowering capacity. Herein, the authors review data from human and animal models of renal disease as well studies in cultured cells with regard to extralipid properties statins. exert lipid-independent benefits against injury experimental states chronic or acute function impairment. These include diabetic hypertensive glomerulosclerosis, autoimmune glomerulonephritis, ischemia/reperfusion-induced damage, unilateral ureteral obstructive nephropathy. Also, statins, by reducing synthesis mevalonate products, inhibit activation Rho Ras guanosine triphosphatases that influence various signaling pathways involving inflammatory, fibrogenic, proliferative, cell-death responses. Therefore, statins anti-inflammatory actions tissue, prevent scarring, diminish mesangial other kidney cell-type proliferation while promoting cell apoptosis. Renal antioxidant consequent endothelial regulation vasculature following statin treatment also account for pleiotropic protection injury.