Statin monotherapy attenuates renal injury in a salt-sensitive hypertension model of renal disease.

作者: JM Vieira Jr , LT Rodrigues , E Mantovani , H Dellê , AL Mattar

DOI: 10.1159/000087576

关键词:

摘要: Background: Several salutary biological effects of statins have been described. We sought to investigate more closely the anti-inflammatory and antiproliferative simvasta

参考文章(39)
Robert S. Rosenson, Christine C. Tangney, Antiatherothrombotic Properties of Statins Implications for Cardiovascular Event Reduction JAMA. ,vol. 279, pp. 1643- 1650 ,(1998) , 10.1001/JAMA.279.20.1643
Carla Zoja, Daniela Corna, Daniela Rottoli, Dario Cattaneo, Cristina Zanchi, Susanna Tomasoni, Mauro Abbate, Giuseppe Remuzzi, Effect of combining ACE inhibitor and statin in severe experimental nephropathy. Kidney International. ,vol. 61, pp. 1635- 1645 ,(2002) , 10.1046/J.1523-1755.2002.00332.X
Guohua Ding, Nicholas Franki, Aditi A. Kapasi, Krishna Reddy, Nora Gibbons, Pravin C. Singhal, Tubular Cell Senescence and Expression of TGF-β1 and p21WAF1/CIP1 in Tubulointerstitial Fibrosis of Aging Rats Experimental and Molecular Pathology. ,vol. 70, pp. 43- 53 ,(2001) , 10.1006/EXMP.2000.2346
J. Megyesi, P. M. Price, E. Tamayo, R. L. Safirstein, The lack of a functional p21WAF1/CIP1 gene ameliorates progression to chronic renal failure Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 10830- 10835 ,(1999) , 10.1073/PNAS.96.19.10830
Ziad A. Massy, Carlos Guijarro, Statins: effects beyond cholesterol lowering Nephrology Dialysis Transplantation. ,vol. 16, pp. 1738- 1741 ,(2001) , 10.1093/NDT/16.9.1738
Allison A. Eddy, , Cecilia M. Giachelli, Elaine Liu, Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney International. ,vol. 47, pp. 1546- 1557 ,(1995) , 10.1038/KI.1995.218
C Baylis, B Mitruka, A Deng, Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. Journal of Clinical Investigation. ,vol. 90, pp. 278- 281 ,(1992) , 10.1172/JCI115849
Stephan Fichtlscherer, Christiane Mildner-Rihm, Stefanie Dimmeler, Alexandra Aicher, Klaudia Adler, Mariuca Vasa, Hans Martin, Hartmut Rütten, Michaela Tiemann, Andreas M. Zeiher, HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway Journal of Clinical Investigation. ,vol. 108, pp. 391- 397 ,(2001) , 10.1172/JCI13152