Hepatic Arterial Infusion Pump Chemotherapy for Colorectal Liver Metastases: Making a Comeback?

摘要: Nearly half of patients diagnosed with colorectal cancer will develop metastases during their lifetime; the majority them were found within liver. Surgical resection liver is only curative therapy 5-year survival rates ranging from 40 to 58 %. Unfortunately, less than 25 % are eligible for resection. Before advent modern systemic chemotherapy era, administration hepatic artery infusion (HAI) was widespread in treatment metastasis (CLM). However, due a lack demonstrated increased following HAI compared alone, its use has fallen out favor. Recently, multiple studies have that may fill role CLM disease who either progressed on first-line palliative setting or considered candidates conversion unresectable resectable liver-only disease. The large randomized clinical trials demonstrating efficacy precluded be standard care outside research adjuvant setting.