Meperidine for patient-controlled analgesia after cesarean section. Intravenous versus epidural administration.

摘要: Background Although meperidine has been used for patient-controlled analgesia both intravenously (PCIA) and epidurally (PCEA), these routes have not compared, many studies suggested that there is no advantage to the epidural route administration of lipophilic opioids. Methods A randomized, double-blind, crossover study was conducted 24 h after cesarean section compare analgesic efficacy, side effects, patient satisfaction, drug use, plasma concentrations with administered either as PCIA or PCEA. Two groups, stratified time during anesthesia, postoperatively received PCEA (group 1) 2) identical variables 12 before crossing other an additional h. Results from 45 patients showed a similar speed onset but, subsequently, significantly lower pain scores at rest coughing in those receiving (P = 0.0001). Nausea pruritus did differ between groups first postoperatively, but sedation were higher Patient satisfaction preference favored - 0.0001), almost 90% participants preferring route. Meperidine use reduced approximately 50% normeperidine Conclusions We conclude section, produces high-quality relief few effects significant advantages over meperidine. With caveat neonatal breast-feeding mothers yet be evaluated, it can highly recommended this population.