The innate antiviral response: new insights into a continuing story.
作者： Andrea Paun , Paula M. Pitha
DOI: 10.1016/S0065-3527(06)69001-5
关键词: Cytoplasmic receptor 、 Biology 、 Antigen 、 Interferon regulatory factors 、 Viral replication 、 Immunology 、 Chemokine 、 Major histocompatibility complex 、 Innate immune system 、 Cytotoxic T cell
摘要: Publisher Summary Antiviral cytokines (interferons or IFNs) and chemokines activated as an early response to infection play important role both in the outcome of viral its virulence. Interferons can inhibit replication directly by inducing antiviral state host cells. Indirect inhibition occurs because increasing expression major histocompatibility complex (MHC) antigens, initiating inflammatory responses, stimulating development cytotoxic T cells well differentiation B into antibody-producing plasma also a crucial activation macrophages natural killer (NK) The interferon regulatory factors (IRFs) critical induction Type I IFN chemokine genes, genes mediating antiviral, antibacterial, responses. innate immune develops rapid regulated defense mechanism which recognition invading pathogenic organism on binding specific cytoplasmic receptor Toll-like (TLR). These TLRs recognize conserved patterns proteins, lipoproteins, double-stranded (ds) RNA, unmethylated CpG DNA that are pathogen-associated molecular (PAMPs).
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