Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression

作者: Effie Apostolou , Dimitris Thanos

DOI: 10.1016/J.CELL.2008.05.052

关键词: BiologyTranscription (biology)GeneEnhancerGene expressionEnhanceosomeTransfectionTranscription factorMolecular biologyNF-κB

摘要: … of the IFN-β gene … factor NF-κB to the IFN-β enhancer, thus triggering enhanceosome assembly and activation of transcription from this allele. The probability of a cell to express IFN-β is …

参考文章(40)
Andrea Paun, Paula M. Pitha, The innate antiviral response: new insights into a continuing story. Advances in Virus Research. ,vol. 69, pp. 1- 66 ,(2006) , 10.1016/S0065-3527(06)69001-5
T Enoch, K Zinn, T Maniatis, Activation of the human beta-interferon gene requires an interferon-inducible factor. Molecular and Cellular Biology. ,vol. 6, pp. 801- 810 ,(1986) , 10.1128/MCB.6.3.801
Dinis Pedro Calado, Tiago Paixão, Dan Holmberg, Matthias Haury, Stochastic monoallelic expression of IL-10 in T cells. Journal of Immunology. ,vol. 177, pp. 5358- 5364 ,(2006) , 10.4049/JIMMUNOL.177.8.5358
Wouter de Laat, Frank Grosveld, Inter-chromosomal gene regulation in the mammalian cell nucleus Current Opinion in Genetics & Development. ,vol. 17, pp. 456- 464 ,(2007) , 10.1016/J.GDE.2007.07.009
Kate Senger, Menie Merika, Theodora Agalioti, Junming Yie, Carlos R Escalante, Guoying Chen, Aneel K Aggarwal, Dimitris Thanos, Gene Repression by Coactivator Repulsion Molecular Cell. ,vol. 6, pp. 931- 937 ,(2000) , 10.1016/S1097-2765(05)00081-X
T. MANIATIS, J.V. FALVO, T.H. KIM, T.K. KIM, C.H. LIN, B.S. PAREKH, M.G. WATHELET, Structure and Function of the Interferon-β Enhanceosome Cold Spring Harbor Symposia on Quantitative Biology. ,vol. 63, pp. 609- 620 ,(1998) , 10.1101/SQB.1998.63.609
Kenya Honda, Akinori Takaoka, Tadatsugu Taniguchi, Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors Immunity. ,vol. 25, pp. 349- 360 ,(2006) , 10.1016/J.IMMUNI.2006.08.009
Christian P. Bacher, Michèle Guggiari, Benedikt Brors, Sandrine Augui, Philippe Clerc, Philip Avner, Roland Eils, Edith Heard, Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nature Cell Biology. ,vol. 8, pp. 293- 299 ,(2006) , 10.1038/NCB1365
Stavros Lomvardas, Dimitris Thanos, Modifying gene expression programs by altering core promoter chromatin architecture. Cell. ,vol. 110, pp. 261- 271 ,(2002) , 10.1016/S0092-8674(02)00822-X