Brain docosahexaenoic acid uptake and metabolism

摘要: Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty in brain where it serves to regulate several important processes and, addition, as a precursor bioactive mediators. Given that capacity of synthesize DHA locally appreciably low, uptake from circulating lipid pools essential maintaining homeostatic levels. Although, plasma have been proposed supply with DHA, recent evidence suggests non-esterified-DHA and lysophosphatidylcholine-DHA are primary sources. The into appears be regulated by number complementary pathways associated activation metabolism may provide mechanisms for enrichment within brain. Following entry brain, esterified recycled amongst membrane phospholipids contributing distribution phospholipids. During neurotransmission following injury, released converted mediators which signaling synaptogenesis, cell survival, neuroinflammation, relevant treating neurological diseases. In present review, we comprehensive overview metabolism, encompassing many key enzymatic regulators governing metabolism. focus on release non-esterified subsequent production their activity We also brief review post-mortem analyses investigating levels context disease mood disorder, highlighting current disparities field.