ACSL6 is critical for maintaining brain DHA levels.

摘要: Docosahexaenoic acid (DHA; 22:6n3) is the most abundant polyunsaturated fatty in brain, where it largely esterified to membrane phospholipids. While DHA found throughout its levels are relatively higher gray matter and especially enriched at synapse (1). a precursor series of bioactive molecules, including specialized proresolving lipid mediators (2) docosahexaenoyl ethanolamide Collectively, regulate, or involved in, numerous processes maintenance fluidity, neuronal survival, synaptic neurotransmission, regulation neuroinflammation, among others. Thus, perhaps not surprisingly, disturbances brain metabolism have been implicated host neurodegenerative psychiatric diseases The importance has led many nutritional studies examining role diet regulating levels; however, mechanistic details regarding uptake into scarce. clear that plasma unesterified can enter (3, 4), molecular mechanisms this process clear. In PNAS, Fernandez et al. (5) find member long-chain acyl-CoA synthetase (ACSL) family, ACSL6, essential for enriching with DHA. DHA omega-3 family acids, which cannot be synthesized de novo generally considered essential. However, itself nutritionally because from dietary α-linolenic via reactions primarily occur liver. Importantly, within synthesis very low. requires constant supply blood replace consumed metabolic reactions. There considerable debate as … [↵][1]1To whom correspondence should addressed. Email: richard.bazinet{at}utoronto.ca. [1]: #xref-corresp-1-1