Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

摘要: Despite being critical for normal brain function, the pools that supply docosahexaenoic acid (DHA) to are not agreed upon. Using multiple kinetic models in free-living adult rats, we first demonstrate DHA uptake from plasma non-esterified fatty (NEFA) pool predicts of upon oral administration, which enters NEFA as well esterified pools. The rate loss by is similar pool. Furthermore, acute iv although more radiolabeled lysophosphatidylcholine (LPC)-DHA than NEFA-DHA, this due longer half-life and exposure brain. Direct comparison LPC-DHA NEFA-DHA demonstrates into 10-fold greater LPC-DHA. In conclusion, major supplying