α-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid
作者： James C. DeMar , Kaizong Ma , Lisa Chang , Jane M. Bell , Stanley I. Rapoport
DOI: 10.1111/J.1471-4159.2005.03258.X
关键词:
摘要: Adult male unanesthetized rats, reared on a diet enriched in both alpha-linolenic acid (alpha-LNA) and docosahexaenoic (DHA), were infused intravenously for 5 min with [1-(14)C]alpha-LNA. Timed arterial samples collected until the animals killed at brain was removed after microwaving. Plasma lipid concentrations radioactivities measured. Within plasma lipids, > 99% of radioactivity form unchanged Eighty-six per cent present as beta-oxidation products, whereas remainder mainly 'stable' phospholipid or triglyceride alpha-LNA DHA. Equations derived from kinetic modeling demonstrated that unesterified unlabeled rapidly enters plasma, but its incorporation into triglyceride, synthesized DHA, is < = 0.2% amount brain. Thus, rats fed containing large amounts largely undergoes beta-oxidation, not an appreciable source DHA within phospholipids.
sci-hub.se 参考文章(77)
Michael C.J. Chang, Jane M. Bell, A. David Purdon, Elsbeth G. Chikhale, Eric Grange, Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. Neurochemical Research. ,vol. 24, pp. 399- 406 ,(1999) , 10.1023/A:1020989701330
W. E. M. Lands, C. G. Crawford, Enzymes of Membrane Phospholipid Metabolism in Animals Springer US. pp. 3- 85 ,(1976) , 10.1007/978-1-4684-2655-7_1
Maggie B. Covington, Omega-3 fatty acids. American Family Physician. ,vol. 70, pp. 133- 140 ,(2004)
Amiya K. Hajra, James E. Bishop, Preparation of radioactive acyl coenzyme A. Methods in Enzymology. ,vol. 122, pp. 50- 53 ,(1986) , 10.1016/0076-6879(86)22147-3
James C. DeMar, Kaizong Ma, Jane M. Bell, Stanley I. Rapoport, Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. Journal of Neurochemistry. ,vol. 91, pp. 1125- 1137 ,(2004) , 10.1111/J.1471-4159.2004.02789.X
Steven A. Moore, Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro. Journal of Molecular Neuroscience. ,vol. 16, pp. 195- 200 ,(2001) , 10.1385/JMN:16:2-3:195
Michael C. J. Chang, Miguel A. Contreras, Thad A. Rosenberger, Jyrki J. O. Rintala, Jane M. Bell, Stanley I. Rapoport, Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers Journal of Neurochemistry. ,vol. 77, pp. 796- 803 ,(2001) , 10.1046/J.1471-4159.2001.00311.X
S.C. Cunnane, New Developments in α-Linolenate Metabolism with Emphasis on the Importance of β-Oxidation and Carbon Recycling World review of nutrition and dietetics. ,vol. 88, pp. 178- 183 ,(2001) , 10.1159/000059751
Miguel A. Contreras, Michael C. J. Chang, Thad A. Rosenberger, Rebecca Sheaff Greiner, Carol S. Myers, Norman Salem, Stanley I. Rapoport, Chronic nutritional deprivation of n-3 α-linolenic acid does not affect n-6 arachidonic acid recycling within brain phospholipids of awake rats Journal of Neurochemistry. ,vol. 79, pp. 1090- 1099 ,(2008) , 10.1046/J.1471-4159.2001.00658.X
Jean-Marie Bourre, Marianne Francois, Ahcène Youyou, Odile Dumont, Michèle Piciotti, Gérard Pascal, Georges Durand, The Effects of Dietary α-Linolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats Journal of Nutrition. ,vol. 119, pp. 1880- 1892 ,(1989) , 10.1093/JN/119.12.1880