Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

作者: Anthony F. Domenichiello , Alex P. Kitson , Richard P. Bazinet

DOI: 10.1016/J.PLIPRES.2015.04.002

关键词:

摘要: … that DHA synthesis from ALA can provide sufficient DHA for … acid (EPA), DHA is the main n-3 PUFA in the brain as it is … ALA-derived DHA is sufficient to maintain brain DHA levels …

参考文章(184)
Riitta Freese, Marja Mutanen, Liisa M Valsta, Irma Salminen, Comparison of the effects of two diets rich in monounsaturated fatty acids differing in their linoleic/alpha-linolenic acid ratio on platelet aggregation Thrombosis and Haemostasis. ,vol. 71, pp. 73- 77 ,(1994) , 10.1055/S-0038-1642387
James C. DeMar, Kaizong Ma, Jane M. Bell, Stanley I. Rapoport, Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. Journal of Neurochemistry. ,vol. 91, pp. 1125- 1137 ,(2004) , 10.1111/J.1471-4159.2004.02789.X
Lynne Shinto, Joseph Quinn, Thomas Montine, Hiroko H. Dodge, William Woodward, Sara Baldauf-Wagner, Dana Waichunas, Lauren Bumgarner, Dennis Bourdette, Lisa Silbert, Jeffrey Kaye, A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease Journal of Alzheimer's Disease. ,vol. 38, pp. 111- 120 ,(2013) , 10.3233/JAD-130722
Stephen C. Cunnane, Julie A. Schneider, Christine Tangney, Jennifer Tremblay-Mercier, Mélanie Fortier, David A. Bennett, Martha Clare Morris, Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease. ,vol. 29, pp. 691- 697 ,(2012) , 10.3233/JAD-2012-110629
Hans Mohrhauer, Kirsten Christiansen, Minerva V. Gan, Manfred Deubig, Ralph T. Holman, Chain elongation of linoleic acid and its inhibition by other fatty acids in vitro. Journal of Biological Chemistry. ,vol. 242, pp. 4507- 4514 ,(1967) , 10.1016/S0021-9258(18)99567-0
A. Voss, M. Reinhart, S. Sankarappa, H. Sprecher, The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. Journal of Biological Chemistry. ,vol. 266, pp. 19995- 20000 ,(1991) , 10.1016/S0021-9258(18)54882-1
James C. DeMar, Kaizong Ma, Lisa Chang, Jane M. Bell, Stanley I. Rapoport, α-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid Journal of Neurochemistry. ,vol. 94, pp. 1063- 1076 ,(2005) , 10.1111/J.1471-4159.2005.03258.X
Rodolfo Roberto Brenner, Raúl Omar Peluffo, Effect of Saturated and Unsaturated Fatty Acids on the Desaturation in Vitro of Palmitic, Stearic, Oleic, Linoleic, and Linolenic Acids Journal of Biological Chemistry. ,vol. 241, pp. 5213- 5219 ,(1966) , 10.1016/S0021-9258(18)96419-7
Miki Igarashi, Kaizong Ma, Fei Gao, Hyung-Wook Kim, Stanley I. Rapoport, Jagadeesh S. Rao, Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer's Disease Prefrontal Cortex Journal of Alzheimer's Disease. ,vol. 24, pp. 507- 517 ,(2011) , 10.3233/JAD-2011-101608