Perinatal 192 IgG-Saporin as Neuroteratogen.
作者： Laura Petrosini , Paola De Bartolo , Debora Cutuli , Francesca Gelfo
关键词: Neuroplasticity 、 Biology 、 Neocortex 、 Amygdala 、 Basal forebrain 、 Neuroscience 、 Cholinergic 、 Cholinergic neuron 、 Olfactory bulb 、 Neurogenesis
摘要: The immunotoxin 192 IgG-saporin selectively destroys basal forebrain cholinergic neurons that provide input to the hippocampus, entire cortical mantle, amygdala, and olfactory bulb. Perinatal immunotoxic lesions by induce long-lasting depletion mimicking a number of developmental disorders reported in humans. perinatal injection induces several brain modifications, which are observed neocortex hippocampus at short long term. These plastic changes involve both structural (alterations volume, neuronal morphology, neurogenesis) molecular (modulations levels neurotransmitters other proteins related neurodegeneration) levels. Moreover, may interact with capacity react injuries. allowed investigating role system modulating behavioral functions developing as well adult rats. After depletion, rats display reduced ultrasonic vocalizations neonates, learning exploratory deficits juveniles, altered discriminative abilities, impulsive perseverative behaviors, memory adults. Overall, these findings underline importance integrity for development specific functional features.
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