Heparin-associated thrombocytopenia: low frequency in 104 patients treated with heparin of intestinal mucosal origin

摘要: A prospective study of 104 patients receiving heparin obtained from porcine intestinal mucosa for 4 or more days was conducted to determine the frequency associated significant thrombocytopenia (platelet count less than 100 x 10(9)/I on 2 consecutive days). No episodes were identified in 13 by continuous intravenous infusion a mean 8.0 38 subcutaneously 9.9 days. In 1 26 as intermittent boluses 8.2 developed; this patient had laboratory evidence disseminated intravascular coagulation. none 17 uninterrupted therapy one route administration but any single did heparin-associated develop. Of platelet counts 150 10(9)/I, most it not possible definitely relate therapy. Platelets normal platelet-rich plasma aggregate when and serum with added. The noted considerably lower that reported previously.