HEPARIN-INDUCED THROMBOCYTOPENIA: ASSOCIATION OF THROMBOTIC COMPLICATIONS WITH HEPARIN-DEPENDENT IgG ANTIBODY THAT INDUCES THROMBOXANE SYNTHESIS AND PLATELET AGGREGATION
作者： B.H. Chong , W.R. Pitney , P.A. Castaldi
DOI: 10.1016/S0140-6736(82)90106-4
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摘要: Abstract Eleven patients in whom thrombocytopenia developed during heparin therapy were studied. Six (group 1) had severe with delayed onset and five of these thromboembolic complications. A serum factor which induced heparin-dependent thromboxane B 2 synthesis, 14 C-serotonin release, platelet aggregation was found all group 1. The shown to be IgG. These findings suggest that the mechanism secondary is immunological associated complications may attributed in-vivo activation prostaglandin pathway by antibody. mild symptomless early onset. In this group, antibody not probably a direct action on platelets.
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